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Studies unpick why bowel cancers become resistant to treatment
cancer cells develop resistance to new targeted cancer treatments by developing changes in a gene called KRAS,... need an additional drug to help curb this resistance. Cetuximab and panitumumab work by blocking a protein called EGFR on cancer... cancer, resistance, EGFR, KRAS, cetuximab,...
Breast cancer gene provides vital clue to bowel cancer drug resistance
gene provides vital clue to bowel cancer drug resistance... gene in tumour samples could be used to predict resistance to anti-EGFR drugs. Tumours with consistently high numbers of copies of... anti-EGFR treatment, anti-EGFR therapy, drug resistance, epidermal growth factor receptor...
Bowel cancers reshuffle their genetic pack to cheat treatment
tumour spread, or contribute to cancer drug resistance. “By unravelling how this process happens we can now look at turning... cancer, chromosomal instability, drug resistance...
Scientists discover why bowel cancer sometimes outsmarts treatment
may be one of the mechanisms behind tumour resistance to chemotherapy but could also represent a potential drug target. If we can...
Research points to why some colorectal cancers recur after treatment
receptors (EGFR), are regulated, leading to resistance. "Our study investigated the role of extracellular methylation in EGFR...